1′-(2-Chlorophenyl)-5,6,5′,6′,7′,7a′-hexahydro-1′H,1′′H-dispiro[imidazo[2,1-b][1,3]thiazole-2,2′-pyrrolizine-3′(2′H),3′′-indole]-2′′,3(2H,3′′H)-dione
نویسندگان
چکیده
منابع مشابه
Pyrrolizine-1,3-dione.
Pyrrolizine-1,3-dione 4 was made by oxidation of the alcohol 2 using pyridinium chlorochromate. The dione 4 shows ketone properties (e.g. formation of DNP derivative 11) and, in common with other pyrrolizinones, the lactam unit is readily ring-opened by methanol under basic conditions. The active methylene unit of 4 couples readily with diazonium salts to provide the hydrazone 15 whose structur...
متن کامل2-(4,5,6,7,8,9-Hexahydro-6a-azaphenylen-2-ylmethylene)indan-1,3-dione
The title compound, C(22)H(19)NO(2), has potential for use as a new nonlinear optical material. Mol-ecules are almost planar. One C atom of the heterocyclic ring system is disordered over two positions; the site occupancy factors are 0.6 and 0.4.
متن کامل5-Bromo-1-(prop-2-en-1-yl)-2,3-dihydro-1H-indole-2,3-dione
In the title compound, C(11)H(8)BrNO(2), the nine-membered fused-ring is nearly planar [maximum deviation = 0.022 (2) Å] and the allyl group is arched over the nine-membered fused-ring at a dihedral angle of 89.2 (1)°. Weak inter-molecular C-H⋯O hydrogen bonding is present in the crystal structure.
متن کامل1′-(2-Chlorophenyl)-5,6,5′,6′,7′,7a′-hexahydro-1′H,1′′H-dispiro[imidazo[2,1-b][1,3]thiazole-2,2′-pyrrolizine-3′(2′H),3′′-indole]-2′′,3(2H,3′′H)-dione
In the title compound, C(24)H(21)ClN(4)O(2)S, the two adjacent spiro junctions link an almost planar (r.m.s. deviation = 0.017 Å) 2-oxindole ring, a hexa-hydro-1H-pyrrolizine ring and a tetra-hydro-imidazo[2,1-b]thia-zole ring. In the crystal, inversion dimers linked by pairs of N-H⋯N hydrogen bonds occur, generating an R(2) (2)(16) loop.
متن کاملMarine Streptomyces Sp. VITMK1 Derived Pyrrolo [1, 2-A] Pyrazine-1, 4-Dione, Hexahydro-3-(2-Methylpropyl) and Its Free Radical Scavenging Activity
Methods: The antioxidant potential of pyrrolo [1, 2-A] pyrazine-1, 4-dione, hexahydro-3-(2-methylpropyl) (diketopiperazine) extracted from Streptomyces sp. VITMK1 was studied using reducing power assay. The scavenging of 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical and nitric oxide (NO) radical by the compound was also studied. The cytotoxic activity of the compound on RAW 264.7 macrophage cel...
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ژورنال
عنوان ژورنال: Acta Crystallographica Section E Structure Reports Online
سال: 2010
ISSN: 1600-5368
DOI: 10.1107/s1600536810009323